As data analytics technology becomes increasingly sophisticated, healthcare informatics—the use of data to improve care delivery and patient health— is essential to meeting the goals of hospitals and health systems today. Big data on patient responses to specific clinical interventions can become the basis for development of evidence-based care practices. Sharing of patient data across the care continuum can improve care coordination. Telehealth to connect patients and providers can bolster care access. But leaders must direct the use—and limit the misuse—of data and analytics packages for informatics to have meaningful impact without breaking the bank.